几种临床常用药物对阿霉素（多柔比星）诱导的小鼠毒性的保护作用。

Protection against adriamycin (doxorubicin)-induced toxicity in mice by several clinically used drugs.

作者信息

Shinozawa S, Gomita Y, Araki Y

出版信息

Acta Med Okayama. 1987 Feb;41(1):11-7. doi: 10.18926/AMO/31766.

Abstract

Protective effects of clinically used drugs against adriamycin (ADM)-induced toxicity were studied in ICR mice. The control mice, which were administered 15 mg/kg of ADM twice, survived 7.48 +/- 1.99 days (mean +/- S.D.). The survival times of mice treated with the following drugs, expressed as a percent of that of the control group, were 293.6% for coenzyme Q10 (Co Q10, 2 mg/kg), 402.2% for dextran sulfate (MDS, 300 mg/kg), 121.6% for flavin adenine dinucleotide (20 mg/kg), 236.3% for adenosine triphosphate disodium (50 mg/kg), 213.7% for reduced glutathione (100 mg/kg), 121.6% for phytonadione (50 mg/kg), 155.2% for inositol nicotinate (Ino-N, 500 mg/kg), 335.5% for nicomol (1000 mg/kg), 157.5% for nicardipine (10 mg/kg) and 123.3% for dipyridamol (50 mg/kg). Anti-hyperlipemic agents such as MDS, nicomol, Ino-N and Co Q10 strongly protected against the ADM-induced toxicity, and the mice administered these drugs lived significantly longer than the control mice. The mechanism of the protective effect was discussed.

摘要

在ICR小鼠中研究了临床使用的药物对阿霉素（ADM）诱导毒性的保护作用。对照组小鼠两次给予15mg/kg的ADM，存活时间为7.48±1.99天（平均值±标准差）。用以下药物治疗的小鼠的存活时间，以对照组存活时间的百分比表示，辅酶Q10（Co Q10，2mg/kg）为293.6%，硫酸葡聚糖（MDS，300mg/kg）为402.2%，黄素腺嘌呤二核苷酸（20mg/kg）为121.6%，三磷酸腺苷二钠（50mg/kg）为236.3%，还原型谷胱甘肽（100mg/kg）为213.7%，维生素K1（50mg/kg）为121.6%，烟酸肌醇酯（Ino-N，500mg/kg）为155.2%，烟醇（1000mg/kg）为335.5%，尼卡地平（10mg/kg）为157.5%，双嘧达莫（50mg/kg）为123.3%。MDS、烟醇、Ino-N和Co Q10等抗高脂血症药物对ADM诱导的毒性有很强的保护作用，给予这些药物的小鼠存活时间明显长于对照组小鼠。讨论了保护作用的机制。