Department of Health Sciences, EMGO Institute, VU University, Amsterdam, The Netherlands.
Eur J Clin Nutr. 2013 Dec;67(12):1277-83. doi: 10.1038/ejcn.2013.167. Epub 2013 Oct 2.
BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up.
SUBJECTS/METHODS: We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6±6.8 years at baseline. We performed linear regression analyses using n-3 and n-6 PUFAs quartiles-assayed by gas liquid chromatography-with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate.
In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0; P for trend <0.001) and 3.4 b.p.m. (1.2, 5.6; P for trend 0.001), respectively. Multivariate longitudinal analyses showed a significant trend across quartiles for alpha-linolenic acid in relation to LVEF. The lowest linoleic acid quartile was significantly associated with a decreased LVEF of -4.0% compared with the highest quartile.
This study found no strong evidence of longitudinal associations of eicosapentaenoic acid and docosahexaenoic acid with echocardiographic measures, however, lower concentrations of alpha-linolenic acid and linoleic acid were associated with decreased LVEF. These results provide evidence for a potential protective role of alpha-linolenic acid and linoleic acid in relation to systolic function.
背景/目的：较低的循环多不饱和脂肪酸（PUFAs）可能导致心脏功能丧失。我们研究了 n-3 和 n-6 PUFAs 浓度较低是否与老年白种人心力超声指标较差和心率较高有关，包括横断面研究和 7 年随访。
研究对象/方法：我们使用了 Hoorn 研究的数据，这是一个基于人群的队列研究。共有 621 名参与者提供了横断面数据，336 名参与者提供了纵向数据。基线时平均年龄为 68.6±6.8 岁。我们使用气相色谱法测定的 n-3 和 n-6 PUFAs 四分位数，通过线性回归分析与左心室射血分数（LVEF）、左心室质量指数、左心房容积指数和心率进行分析。
多变量分析（回归系数（95%置信区间）），与最高四分位相比，最低的二十碳五烯酸和二十二碳六烯酸四分位与较低的 LVEF 呈横断面相关。较低的二十碳五烯酸和二十二碳六烯酸浓度与较高的心率相关：3.7 b.p.m.（1.5，6.0；趋势 P<0.001）和 3.4 b.p.m.（1.2，5.6；趋势 P=0.001）。多变量纵向分析显示，α-亚麻酸与 LVEF 呈显著的四分位趋势。与最高四分位相比，最低的亚油酸四分位与 LVEF 降低 -4.0%显著相关。
本研究未发现二十碳五烯酸和二十二碳六烯酸与超声心动图指标的纵向关联有较强的证据，但 α-亚麻酸和亚油酸浓度较低与 LVEF 降低有关。这些结果为 α-亚麻酸和亚油酸与收缩功能之间可能存在保护作用提供了证据。
