Department of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam, Amsterdam, The Netherlands.
Eur J Clin Nutr. 2012 Jun;66(6):736-41. doi: 10.1038/ejcn.2011.195. Epub 2011 Nov 23.
BACKGROUND/OBJECTIVES: N-3 polyunsaturated fatty acids (PUFAs) have been associated with reduced inflammation. We tested the hypothesis that high serum concentrations of the n-3 PUFAs are associated with lower serum C-reactive protein (CRP) concentrations in healthy middle-aged Finnish men. We also examined whether exposure to mercury, an environmental contaminant in fish, which is also a major source of long-chain n-3 PUFA, was associated with CRP.
SUBJECTS/METHODS: Data from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study were analyzed cross-sectionally to determine the associations between serum n-3 PUFAs, hair mercury and serum CRP in 1395 healthy men, aged 42-60 years. Linear regression analyses were performed to analyze the associations.
In the multivariate models, the mean serum CRP in quartiles of serum total n-3 PUFA concentration was 1.23, 1.27, 1.18 and 1.08 mg/l, P for trend = 0.01. Statistically significant inverse associations were also observed with the total serum long-chain n-3 PUFA concentration and with the individual long-chain n-3 PUFAs docosapentaenoic acid and docosahexaenoic acid, but not with eicosapentaenoic acid or with the intermediate-chain n-3 PUFA alpha-linolenic acid. Hair methylmercury content was not associated with serum CRP levels and it did not modify the associations between serum n-3 PUFAs and CRP either.
Serum n-3 PUFAs and especially the long-chain n-3 PUFA concentration, a marker of fish or fish oil consumption, were inversely associated with serum CRP in men. Exposure to mercury was not associated with serum CRP.
背景/目的：n-3 多不饱和脂肪酸（PUFAs）与炎症减少有关。我们检验了这样一个假设，即高血清 n-3 PUFAs 浓度与健康中年芬兰男性血清 C 反应蛋白（CRP）浓度降低有关。我们还检查了暴露于汞（一种鱼类中的环境污染物，也是长链 n-3 PUFAs 的主要来源）是否与 CRP 有关。
研究对象/方法：对前瞻性、基于人群的库奥皮奥缺血性心脏病危险因素研究的数据进行了横断面分析，以确定 1395 名 42-60 岁健康男性血清 n-3 PUFAs、头发汞和血清 CRP 之间的关联。进行线性回归分析来分析这些关联。
在多变量模型中，血清总 n-3 PUFA 浓度四分位血清 CRP 分别为 1.23、1.27、1.18 和 1.08 mg/l，趋势 P 值=0.01。与总血清长链 n-3 PUFA 浓度以及个体长链 n-3 PUFAs 二十二碳五烯酸和二十二碳六烯酸呈显著负相关，但与二十碳五烯酸或中间链 n-3 PUFA α-亚麻酸无关。头发甲基汞含量与血清 CRP 水平无关，也不能改变血清 n-3 PUFAs 与 CRP 之间的关联。
血清 n-3 PUFAs，特别是长链 n-3 PUFA 浓度，作为鱼类或鱼油消费的标志物，与男性血清 CRP 呈负相关。接触汞与血清 CRP 无关。
