Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Int J Mol Sci. 2013 Sep 30;14(10):19782-91. doi: 10.3390/ijms141019782.
To determine serum osteocalcin levels in South Chinese males with non-alcoholic fatty liver disease (NAFLD) and to examine the relation between serum osteocalcin and NAFLD.
Data were collected from 1683 men attending the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) from September 2009 to December 2009. Serum osteocalcin was measured with electrochemiluminescence immunoassay. An abdominal ultrasonographic examination for all individuals was performed by two experienced ultrasonographers. The associations of serum osteocalcin with NAFLD were evaluated.
The levels of serum osteocalcin were lower in 364 NAFLD participants than in 1319 non-NAFLD participants (24.51 ± 1.38 ng/mL vs. 20.81 ± 1.33 ng/mL, p < 0.001). Serum osteocalin level was associated with the scale of NAFLD (r = -0.150, p < 0.01). Serum osteocalin level tended to decrease with the scale of NAFLD. Binary logistic regression analysis showed that decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles.
Our findings suggest that a lower serum osteocalcin level is associated with the presence of NAFLD.
测定中国南方男性非酒精性脂肪性肝病（NAFLD）患者的血清骨钙素水平，并探讨血清骨钙素与 NAFLD 的关系。
本研究数据来自 2009 年 9 月至 12 月参加防城港市男性健康体检研究（FAMHES）的 1683 名男性。采用电化学发光免疫分析法检测血清骨钙素。由两名有经验的超声医师对所有个体进行腹部超声检查。评估血清骨钙素与 NAFLD 的相关性。
364 名 NAFLD 患者的血清骨钙素水平低于 1319 名非 NAFLD 患者（24.51 ± 1.38 ng/mL 比 20.81 ± 1.33 ng/mL，p < 0.001）。血清骨钙素水平与 NAFLD 严重程度相关（r = -0.150，p < 0.01）。血清骨钙素水平随着 NAFLD 严重程度的增加而降低。二项逻辑回归分析显示，随着血清骨钙素四分位数的降低，NAFLD 的比值比呈下降趋势。
本研究结果表明，血清骨钙素水平降低与 NAFLD 的发生有关。
