Technische Universität Braunschweig, Institut für Organische Chemie, Hagenring 30, 38106 Braunschweig, Germany.
Org Biomol Chem. 2013 Nov 21;11(43):7447-50. doi: 10.1039/c3ob41755g.
The biosynthesis of tricho-acorenol in Trichoderma harzianum was investigated by feeding stereospecifically deuterated mevalonolactone isotopomers, followed by a detailed GC/MS analysis of the incorporation of labelling. The results establish a highly stereospecific hydride migration and antarafacial attack of water in the terminal step towards tricho-acorenol.
我们通过立体特异性地喂养氘代甲羟戊酸内酯同位素异构体，研究了哈茨木霉中三刺-acorenol 的生物合成，随后通过详细的 GC/MS 分析了标记的掺入情况。结果确定了在朝向三刺-acorenol 的最后一步中，高度立体特异性的氢迁移和反式亲核进攻水。
