Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No. 55, Sec. 4, Renminnan Road, Chengdu, 610041, Sichuan, People's Republic of China.
Clin Transl Oncol. 2014 Jun;16(6):539-47. doi: 10.1007/s12094-013-1115-0. Epub 2013 Oct 2.
The present study was carried out to analyze the interstitial fluid pressure (IFP) values in patients with oral squamous cell carcinoma and identify the relationship between the IFP and tumor prognosis.
We investigated tumor lymphatic metastasis-related protein (VEGFC, VEGFD and VEGFR3) expressions change on SCC-4 and SCC-9 cells subjected to increased extracellular pressure in vitro and analyzed the relationship between these proteins and IFP, and prognosis of patients with oral squamous cell carcinoma.
The results showed that the elevated extracellular pressure significantly resulted in a dramatic increase of VEGFC, VEGFD and VEGFR3 protein expressions in OSCC. More important, the activation of VEGFC, VEGFD and VEGFR3 proteins through IFP elevation contributed to poor prognosis for patients with OSCC.
These results suggest an important potential clinical application of measuring IFP, which can be used as a generic marker of prognosis evaluation and response to therapy. Furthermore, VEGFC, VEGFD and VEGFR3 may be useful targets in developing novel and specific therapeutic tool for OSCC patients with high IFP.
本研究旨在分析口腔鳞状细胞癌患者的间质液压力（IFP）值，并确定 IFP 与肿瘤预后之间的关系。
我们研究了体外增加细胞外压力对 SCC-4 和 SCC-9 细胞中肿瘤淋巴管生成相关蛋白（VEGFC、VEGFD 和 VEGFR3）表达变化的影响，并分析了这些蛋白与 IFP 以及口腔鳞状细胞癌患者预后之间的关系。
结果表明，升高的细胞外压力显著导致 OSCC 中 VEGFC、VEGFD 和 VEGFR3 蛋白表达的急剧增加。更重要的是，IFP 升高激活 VEGFC、VEGFD 和 VEGFR3 蛋白与 OSCC 患者的不良预后有关。
这些结果表明测量 IFP 具有重要的潜在临床应用价值，可作为预后评估和治疗反应的通用标志物。此外，VEGFC、VEGFD 和 VEGFR3 可能是针对高 IFP 的 OSCC 患者开发新型特异性治疗工具的有用靶点。
