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新近移民群体中的自闭症。

Autism in a recently arrived immigrant population.

机构信息

Department of Child and Adolescent Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, James's St, Dublin 8, Ireland,

出版信息

Eur J Pediatr. 2014 Mar;173(3):337-43. doi: 10.1007/s00431-013-2149-6. Epub 2013 Oct 2.

DOI:10.1007/s00431-013-2149-6
PMID:24085582
Abstract

UNLABELLED

This study aims to establish whether children of an immigrant maternal population presented with a higher rate of autism than the indigenous population and to explore their presentation with regard to severity of symptoms, demographics and ethnicity. It is a retrospective case note analysis of 366 children who presented to the paediatric developmental service in the Adelaide and Meath incorporating the National Children's Hospital, Tallaght, Ireland between 2007 and 2009. During the study period, 366 children presented. Fifty-eight children (16 %) had mothers who were born in Africa and 53 (14 %) were born to mothers originating from a wider variety of countries. Two hundred and forty-eight children (68 %) had mothers born in Ireland. Maternal origin was not identified for seven children (2 %). An autistic spectrum disorder (ASD) was diagnosed in 131 children and speech and language delay in 132. Of the children with an ASD diagnosis, a higher proportion of the African cohort 13/18 (72.2 %) presented with moderate/severe cognitive disability compared to the Irish group 9/55(16.3 %), and the children in the African cohort showed a higher heritability with 36.9 % having a positive family history of autism reported compared to 26.3 % of the Irish cohort with an ASD diagnosis.

CONCLUSION

This study highlights an observation of increased rates of ASD among a migrant population derived particularly from children born to mothers originating in Sub-Saharan Africa. This cohort is more severely affected. Further validation in an epidemiological sample is warranted, which if replicated, may help to identify possible aetiological risk factors.

摘要

本研究旨在确定移民母亲群体的儿童是否比本土人口更容易出现自闭症,并探讨其症状严重程度、人口统计学和种族方面的表现。这是对 2007 年至 2009 年间在爱尔兰都柏林阿德莱德和米思国家儿童医院儿科发育服务中心就诊的 366 名儿童的病历回顾性分析。在研究期间,共有 366 名儿童就诊。58 名儿童(16%)的母亲出生于非洲,53 名儿童(14%)的母亲来自更广泛的国家。248 名儿童(68%)的母亲出生于爱尔兰。有 7 名儿童(2%)的母亲原籍无法确定。131 名儿童被诊断为自闭症谱系障碍(ASD),132 名儿童有言语和语言延迟。在被诊断为 ASD 的儿童中,非洲组的比例较高,18 名儿童中有 13 名(72.2%)存在中度/重度认知障碍,而爱尔兰组 55 名儿童中有 9 名(16.3%),非洲组的儿童遗传率更高,有 36.9%的儿童有自闭症阳性家族史,而爱尔兰组 ASD 诊断阳性家族史的比例为 26.3%。

结论

本研究强调了在移民人群中观察到的自闭症发病率增加,尤其是源自撒哈拉以南非洲的儿童。该队列的病情更严重。需要在流行病学样本中进一步验证,如果得到复制,这可能有助于确定可能的病因风险因素。

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Global prevalence of autism and other pervasive developmental disorders.全球自闭症和其他普遍性发育障碍的患病率。
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