Occupational Health Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Am J Ind Med. 2014 Feb;57(2):254-7. doi: 10.1002/ajim.22257. Epub 2013 Sep 20.
Dichloromethane is a widely used organic solvent. Occupational exposure to dichloromethane is frequent and can result in both acute and chronic toxicity, affecting mostly the central nervous system, directly or through its metabolite, carbon monoxide. The effects of dichloromethane on the peripheral nervous system are debated. Here we report the case of a 37-year-old woman who was accidentally exposed to dichloromethane. In the days following the incident she experienced bilateral hypoacusis. Hearing loss regressed after 25 days treatment with hyperbaric oxygen. This is the first report of sudden hearing loss after acute exposure to dichloromethane, suggesting a possible toxic effect of this solvent on the auditory system.
二氯甲烷是一种广泛使用的有机溶剂。职业性接触二氯甲烷较为常见,可导致急性和慢性毒性,主要影响中枢神经系统,直接或通过其代谢产物一氧化碳产生影响。二氯甲烷对周围神经系统的影响存在争议。在此,我们报告了 1 例 37 岁女性患者,她意外暴露于二氯甲烷。在事件发生后的几天里,她出现双侧听力下降。接受高压氧治疗 25 天后,听力损失恢复。这是首例急性接触二氯甲烷后发生突发性听力损失的报告,提示这种溶剂对听觉系统可能具有毒性作用。