Klinikum rechts der Isar, Technische Universität München, I. Medical Department, Cardiology, 81675 Munich, Germany.
Cold Spring Harb Perspect Med. 2013 Oct 1;3(10):a013847. doi: 10.1101/cshperspect.a013847.
The mammalian heart is a highly specialized organ, comprised of many different cell types arising from distinct embryonic progenitor populations during cardiogenesis. Three precursor populations have been identified to contribute to different myocytic and nonmyocytic cell lineages of the heart: cardiogenic mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells (CNCCs). This review will focus on molecular cues necessary for proper induction, expansion, and lineage-specific differentiation of these progenitor populations during cardiac development in vivo. Moreover, we will briefly discuss how the knowledge gained on embryonic heart progenitor biology can be used to develop novel therapeutic strategies for the management of congenital heart disease as well as for improvement of cardiac function in ischemic heart disease.
哺乳动物的心脏是一个高度专业化的器官，由在心脏发生过程中来自不同胚胎祖细胞群体的许多不同细胞类型组成。已经鉴定出三个前体群体有助于心脏的不同心肌细胞和非心肌细胞谱系：心脏中胚层细胞（CMC）、心外膜（PE）和心脏神经嵴细胞（CNCCs）。本综述将重点介绍在体内心脏发育过程中，这些祖细胞群体正确诱导、扩增和谱系特异性分化所需的分子线索。此外，我们还将简要讨论胚胎心脏祖细胞生物学方面的知识如何用于开发治疗先天性心脏病的新策略，以及改善缺血性心脏病中心脏功能。
