调控心脏发育的基因网络。
Genetic networks governing heart development.
作者信息
Waardenberg Ashley J, Ramialison Mirana, Bouveret Romaric, Harvey Richard P
机构信息
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia Stem Cells Australia, Melbourne Brain Centre, University of Melbourne, Victoria 3010, Australia.
出版信息
Cold Spring Harb Perspect Med. 2014 Oct 3;4(11):a013839. doi: 10.1101/cshperspect.a013839.
Abstract
Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.
摘要
动物基因组包含从受精卵构建身体蓝图的编码。理解基因组信息如何被解读以创建驱动生物体发育的复杂多层调控系统，以及这些系统在疾病中如何发生改变，是生物科学面临的最大挑战之一。有效表示和传达基因调控网络中固有复杂性的方法的发展仍然是一个主要障碍。本综述介绍了系统生物学的理念，并讨论了在系统生物学层面理解心脏发育方面的最新进展。
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本文引用的文献
1
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Anat Rec (Hoboken). 2014 Aug;297(8):1414-29. doi: 10.1002/ar.22949. Epub 2014 May 27.
2
A proliferative burst during preadolescence establishes the final cardiomyocyte number.青春期前的增殖爆发确立了心肌细胞的最终数量。
Cell. 2014 May 8;157(4):795-807. doi: 10.1016/j.cell.2014.03.035.
3
The rise of regulatory RNA.调控 RNA 的兴起。
Nat Rev Genet. 2014 Jun;15(6):423-37. doi: 10.1038/nrg3722. Epub 2014 Apr 29.
4
Somatic Cell Reprogramming into Cardiovascular Lineages.体细胞重编程为心血管谱系细胞
J Cardiovasc Pharmacol Ther. 2014 Jul;19(4):340-349. doi: 10.1177/1074248414527641. Epub 2014 Apr 23.
5
Re-activated adult epicardial progenitor cells are a heterogeneous population molecularly distinct from their embryonic counterparts.重新激活的成年心外膜祖细胞是一个分子组成上与其胚胎对应物不同的异质群体。
Stem Cells Dev. 2014 Aug 1;23(15):1719-30. doi: 10.1089/scd.2014.0019. Epub 2014 May 8.
6
A promoter-level mammalian expression atlas.一个启动子水平的哺乳动物表达图谱。
Nature. 2014 Mar 27;507(7493):462-70. doi: 10.1038/nature13182.
7
A common genetic variant within SCN10A modulates cardiac SCN5A expression.一种常见的 SCN10A 基因变异可调节心脏 SCN5A 的表达。
J Clin Invest. 2014 Apr;124(4):1844-52. doi: 10.1172/JCI73140. Epub 2014 Mar 18.
8
Missing links in cardiology: long non-coding RNAs enter the arena.心脏病学中的缺失环节：长非编码 RNA 进入舞台。
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9
Enhancer biology and enhanceropathies.增强子生物学与增强子病。
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