Waardenberg Ashley J, Ramialison Mirana, Bouveret Romaric, Harvey Richard P
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia Stem Cells Australia, Melbourne Brain Centre, University of Melbourne, Victoria 3010, Australia.
Cold Spring Harb Perspect Med. 2014 Oct 3;4(11):a013839. doi: 10.1101/cshperspect.a013839.
Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.
动物基因组包含从受精卵构建身体蓝图的编码。理解基因组信息如何被解读以创建驱动生物体发育的复杂多层调控系统，以及这些系统在疾病中如何发生改变，是生物科学面临的最大挑战之一。有效表示和传达基因调控网络中固有复杂性的方法的发展仍然是一个主要障碍。本综述介绍了系统生物学的理念，并讨论了在系统生物学层面理解心脏发育方面的最新进展。
