Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell Stem Cell. 2013 Mar 7;12(3):275-84. doi: 10.1016/j.stem.2013.02.008.
Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.
寻找心血管疾病的治疗方法仍然是一个未满足的主要医学需求。最近的研究开始揭示哺乳动物心脏再生的机制。对低等脊椎动物和哺乳动物动物模型的再生机制的研究为实验激活心脏的促再生反应提供了线索。与此同时，内源性成体干细胞群体的利用以及最近的重编程技术的应用，为针对心脏病的治疗方法的发展带来了重大期望。这些新方法共同使我们更接近于治疗心脏病的更成功策略。
