果蝇中的 Myc 功能。
Myc function in Drosophila.
机构信息
Julius-Maximilians-Universität Würzburg, Lehrstuhl für Biochemie und Molekularbiologie, Am Hubland, 97074 Würzburg, Germany.
出版信息
Cold Spring Harb Perspect Med. 2013 Oct 1;3(10):a014324. doi: 10.1101/cshperspect.a014324.
Abstract
Drosophila contains a single MYC gene. Like its vertebrate homologs, it encodes a transcription factor that activates many targets, including prominently genes involved in ribosome biogenesis and translation. This activity makes Myc a central regulator of growth and/or proliferation of many cell types, such as imaginal disc cells, polyploid cells, stem cells, and blood cells. Importantly, not only does Myc act cell autonomously but it also affects the fate of adjacent cells and tissues. This potential of Myc is harnessed by many different signaling pathways, involving, among others, Wg, Dpp, Hpo, ecdysone, insulin, and mTOR.
摘要
果蝇含有一个单一的 MYC 基因。像它的脊椎动物同源物一样，它编码一种转录因子，可激活许多靶标，包括明显参与核糖体生物发生和翻译的基因。这种活性使 Myc 成为许多细胞类型（如 imaginal disc 细胞、多倍体细胞、干细胞和血细胞）生长和/或增殖的中央调节剂。重要的是，Myc 不仅具有细胞自主性，而且还会影响相邻细胞和组织的命运。Myc 的这种潜力被许多不同的信号通路所利用，这些通路涉及 Wg、Dpp、Hpo、蜕皮激素、胰岛素和 mTOR 等。
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