Sunderland C A, Sasagawa M, Kanazawa K, Stirrat G M, Takeuchi S
Br J Cancer. 1985 Jun;51(6):809-14. doi: 10.1038/bjc.1985.126.
Two cases of gestational choriocarcinoma have been examined for the expression of HLA and trophoblast antigens using the indirect immunoperoxidase technique on frozen tissue sections. Approximately 40-70% of tumour cells express MHC Class I antigen as detected by a panel of antibodies to monomorphic, or framework, MHC Class I antigenic determinants. Evidence in one case suggests that most of these cells may not express the paternal, polymorphic HLA antigenic determinants but that a small subpopulation do carry the fully antigenically active molecule. These latter may give rise to patient anti-paternal HLA antibodies. Class II (HLA DR or DC) antigens are expressed by none, or very few, tumour cells.
利用间接免疫过氧化物酶技术对两例妊娠性绒毛膜癌的冰冻组织切片进行了 HLA 和滋养层抗原表达检测。通过一组针对单态性或构架性 MHC Ⅰ类抗原决定簇的抗体检测发现，约 40% - 70%的肿瘤细胞表达 MHC Ⅰ类抗原。其中一个病例的证据表明，这些细胞中的大多数可能不表达父系多态性 HLA 抗原决定簇，但有一小部分亚群确实携带完全具有抗原活性的分子。后者可能会引发患者产生抗父系 HLA 抗体。Ⅱ类（HLA - DR 或 DC）抗原在肿瘤细胞中无表达或极少表达。
