Silvers W K, Poole T W
J Immunol. 1975 Oct;115(4):1117-21.
A series of experiments were undertaken in mice and rats to confirm the report that foster nursing rats of one strain, on mothers of a different strain, can influence their survival and immunologic competence as a consequence of their receiving a significant number of immunologically competent leukocytes via the milk. These experiments have included foster nursing mice and rats, either immediately after birth, or when 25 to 36 hr old, on H-2 incompatible and Ag-B compatible and incompatible mothers, respectively, and challenging them with ear skin grafts of the same genotype as their surrogate mother. They also have included fostering animals rendered tolerant of their surrogate mother's transplantation antigens. In no instance was any evidence obtained that foster nursing can prejudice the survival or influence the immunologic competence of mice or rats.
在小鼠和大鼠身上进行了一系列实验，以证实一项报告，即一种品系的代乳大鼠由不同品系的母鼠哺育，由于它们通过乳汁获得大量具有免疫活性的白细胞，可能会影响其存活率和免疫能力。这些实验包括分别在出生后立即或在25至36小时大时，将小鼠和大鼠由H-2不相容以及Ag-B相容和不相容的母鼠代乳，并对它们进行与其代乳母亲相同基因型的耳部皮肤移植挑战。实验还包括哺育对代乳母亲移植抗原产生耐受的动物。在任何情况下，均未获得任何证据表明代乳会损害小鼠或大鼠的存活率或影响其免疫能力。
