Buzsáki G, Rappelsberger P, Kellényi L
Electroencephalogr Clin Neurophysiol. 1985 Jul;61(1):77-88. doi: 10.1016/0013-4694(85)91075-2.
Wave shape patterns and spectral properties of hippocampal slow wave activity (RSA) were studied in behaving rats equipped with stationary recording/stimulating electrodes and a movable microelectrode. RSA waves had maximum power at about the hippocampal fissure, and two minima just below the pyramidal cells of CA1 and the inner molecular layer of the dentate gyrus, respectively. The phase profile of RSA was gradual during both running and lever pressing, but the two profiles showed phase differences in the stratum radiatum of CA1 and the hilus. Averaged RSA waves consisted of fast rising and slow decaying components, giving a saw-tooth like pattern. RSA waves were more asymmetric during running than during lever pressing. The slow component showed a sudden polarity reversal below the pyramidal layer of CA1. The fast component of RSA showed a gradual shift and change of the slope with depth. An additional small amplitude wave riding on the slow component ('notch') was present during running. The amplitude increase of the 'notch' occasionally caused frequency doubling of RSA and consequent high power of the second harmonic. The gradual shift and change of the fast component are explained by the hypothesis that somatic inhibitory and dendritic excitatory RSA dipoles in CA1 and dentate gyrus are active at different times of the RSA cycle.
在配备固定记录/刺激电极和可移动微电极的行为大鼠中，研究了海马慢波活动（RSA）的波形模式和频谱特性。RSA波在海马裂附近具有最大功率，在CA1锥体细胞下方和齿状回内分子层下方分别有两个最小值。在跑步和按压杠杆期间，RSA的相位分布都是逐渐变化的，但在CA1辐射层和海马回中，这两种分布存在相位差异。平均RSA波由快速上升和缓慢衰减的成分组成，呈现出锯齿状模式。与按压杠杆期间相比，跑步期间RSA波更不对称。慢成分在CA1锥体细胞层下方显示出突然的极性反转。RSA的快成分随深度呈现出逐渐的偏移和斜率变化。在跑步期间，慢成分上叠加有一个额外的小振幅波（“凹口”）。“凹口”的振幅增加偶尔会导致RSA频率加倍，进而产生二次谐波的高功率。快成分的逐渐偏移和变化可以用以下假设来解释：CA1和齿状回中的体细胞抑制性和树突兴奋性RSA偶极在RSA周期的不同时间活跃。
