存在或不存在组装：进入核肌动蛋白丝。
To be or not to be assembled: progressing into nuclear actin filaments.
机构信息
Biochemical-Pharmacological Center (BPC), Institute of Pharmacology, University of Marburg, 35043 Germany.
出版信息
Nat Rev Mol Cell Biol. 2013 Nov;14(11):693-7. doi: 10.1038/nrm3681. Epub 2013 Oct 3.
The paradigm states that cytoplasmic actin operates as filaments and nuclear actin is mainly monomeric, acting as a scaffold in transcription complexes. However, why should a powerful function of actin, namely polymerization, not be used in the nucleus? Recent progress in the field forces us to rethink this issue, as many actin filament assembly proteins have been linked to nuclear functions and new experimental approaches have provided the first direct visualizations of polymerized nuclear actin.
该范式表明细胞质肌动蛋白作为纤维起作用，而核肌动蛋白主要是单体，作为转录复合物中的支架。然而，为什么肌动蛋白的一个强大功能，即聚合，不在核内发挥作用呢？该领域的最新进展迫使我们重新思考这个问题，因为许多肌动蛋白丝组装蛋白已与核功能相关联，并且新的实验方法提供了聚合核肌动蛋白的首次直接可视化。
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