Harting Brian, Johnson Tricia, Abrams Richard, Odwazny Richard, Hasler Scott, McNutt Robert
Department of Medicine, Rush University Medical Center (Dr Harting, Abrams, Odwazny, Hasler, and McNutt), and Department of Health Systems Management, Rush University (Dr Johnson), Chicago, Illinois. This project was supported by grant number U19HS021093 from the Agency for Healthcare Research and Quality. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality.
Qual Manag Health Care. 2013 Oct-Dec;22(4):322-6. doi: 10.1097/QMH.0000000000000009.
We explored the associations between opioid dose and multiple measures of pain.
Thirty-two consecutive patients admitted solely for an acute exacerbation of cancer-related pain or for surgery were followed for their entire hospital stay (115 days of pain). For each hospital day, we collected pain scores, the number of pain scores, trends in pain scores, the percentage of time patients had 100% acceptable relief from pain, and the number of times patients were asked about acceptable pain relief. Finally, we asked those who had 100% relief of pain whether they could have used more pain medicine. Linear regression models were fit to estimate the amount of variation explained (R) in dose of medication, by each pain measurement variable.
Nineteen patients with cancer (74 days of pain) and 13 patients undergoing surgery (41 days of pain) were evaluated. Pain scores, the number of pain scores, trends in pain scores, and 100% acceptable relief scores poorly correlated with the use of medication in the linear regression models (R for all models ≤0.2). A question about needing more pain medicine explained the greatest amount of variation in opioid dose.
Pain and acceptable relief scores do not adequately reflect the use of medication. A prospective study is needed to further assess the value of additional measures of the adequacy of pain care.
我们探讨了阿片类药物剂量与多种疼痛指标之间的关联。
对32例仅因癌症相关疼痛急性加重或手术入院的连续患者进行了为期整个住院期间(115天的疼痛观察期)的随访。对于每个住院日,我们收集了疼痛评分、疼痛评分次数、疼痛评分趋势、患者疼痛完全缓解达到可接受程度的时间百分比,以及询问患者可接受疼痛缓解情况的次数。最后,我们询问那些疼痛完全缓解的患者是否本可以使用更多的止痛药。采用线性回归模型来估计每个疼痛测量变量对药物剂量变异解释量(R)。
对19例癌症患者(74天疼痛观察期)和13例接受手术患者(41天疼痛观察期)进行了评估。在线性回归模型中,疼痛评分、疼痛评分次数、疼痛评分趋势以及疼痛完全缓解达到可接受程度的评分与药物使用的相关性较差(所有模型的R≤0.2)。关于是否需要更多止痛药的问题解释了阿片类药物剂量变异的最大部分。
疼痛和可接受缓解评分不能充分反映药物的使用情况。需要进行一项前瞻性研究,以进一步评估疼痛护理充分性的其他测量指标的价值。