在甲醛氨基衍生物存在下，聚（dG-dC）·聚（dG-dC）中的B-Z转变
B-Z transition in poly(dG-dC).poly(dG-dC) in the presence of formaldehyde amino derivatives.
作者信息
Poverenny A M, Kiseleva V I, Tyaglov B V, Permogorov V I
出版信息
FEBS Lett. 1985 Jul 8;186(2):197-200. doi: 10.1016/0014-5793(85)80707-9.
PMID:2408922
Abstract
It was shown by circular dichroism that the B-Z transition of poly(dG-dC).poly(dG-dC) in high NaCl concentrations occurred more rapidly in the presence of formaldehyde and Tris. The product of formaldehyde and glycine interaction induces changes in the poly(dG-dC).poly(dG-dC) CD spectral characteristics of a 'B-like' conformation. It is supposed that the B-Z transition occurs without large-scale hydrogen bond breakage.
摘要
圆二色性表明，在高浓度氯化钠中，聚（dG-dC）·聚（dG-dC）的B-Z转变在甲醛和Tris存在的情况下发生得更快。甲醛与甘氨酸相互作用的产物会引起聚（dG-dC）·聚（dG-dC）“类B”构象的圆二色光谱特征发生变化。据推测，B-Z转变的发生没有大规模氢键断裂。
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