Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.
Laryngoscope. 2014 Mar;124(3):711-7. doi: 10.1002/lary.24311. Epub 2013 Sep 17.
OBJECTIVES/HYPOTHESIS: To measure the swallowing pressure (SP) of normal subjects using a 2.64-mm-diameter high-resolution manometry (HRM) catheter with 36 circumferential sensors.
Repeated measures with subjects serving as controls.
Thirty healthy subjects swallowed water at different temperatures and volumes to examine the maximum SP at the velopharynx, meso-hypopharynx, upper esophageal sphincter (UES), and cervical esophagus, and the duration of lowered pressure at the UES.
The maximum SP at any location was unaffected by the volume of water, whereas the maximum SP at the UES and cervical esophagus was affected by the temperature. The duration of lowered SP at the UES was significantly prolonged with 10 versus 2 mL of cold water. The pressure curve in males had two peaks (at the velopharynx and UES), whereas that of females had a single peak at the UES.
Our data obtained with 2.64-mm HRM demonstrated that as the bolus volume is increased, the duration of lowered SP at the UES is prolonged. The higher maximum SP at the velopharynx in males versus females suggests that there may be a gender difference in pressure at the velopharynx that has not been described previously. This implies that it is necessary to take gender differences into consideration when evaluating the etiology of swallowing dysfunction by examining the SP and SP curve. Moreover, the thinner catheter is less invasive and may contribute to obtaining more physiological measurements.
目的/假设：使用带有 36 个圆周传感器的 2.64 毫米直径高分辨率测压（HRM）导管测量正常受试者的吞咽压力（SP）。
以受试者为对照的重复测量。
30 名健康受试者吞咽不同温度和体积的水，以检查咽腔、中咽、上食管括约肌（UES）和颈段食管的最大 SP 以及 UES 下压力持续时间。
任何部位的最大 SP 均不受水体积的影响，而 UES 和颈段食管的最大 SP 则受温度的影响。与 10 毫升相比，10 毫升和 2 毫升冰水会显著延长 UES 下压力持续时间。男性的压力曲线有两个峰值（在咽腔和 UES），而女性的压力曲线在 UES 处只有一个峰值。
我们使用 2.64 毫米 HRM 获得的数据表明，随着吞咽量的增加，UES 下压力持续时间延长。男性 UES 处的最大 SP 高于女性，表明 UES 处的压力可能存在以前未描述过的性别差异。这意味着在通过检查 SP 和 SP 曲线评估吞咽功能障碍的病因时，有必要考虑性别差异。此外，更细的导管侵入性更小，可能有助于获得更生理的测量。
