Monoclonal antibodies to digoxin: comparison of in vitro and in vivo immunization.
作者信息
Buchman D, Miller D, Koch G
出版信息
Hybridoma. 1985 Summer;4(2):173-7. doi: 10.1089/hyb.1985.4.173.
PMID:2408991
Abstract
We compared the primary response in vitro with the secondary response in vivo of A/J inbred and CD-1 outbred mice to digoxin-HSA. The frequencies of hybrid formation and growth, and of the hybridomas that secreted antibody to digoxin were similar in both strains regardless of the immunization procedure. The patterns of cross-reactivity of the monoclonal antibodies to two compounds structurally related to digoxin (ouabain and digitoxin) were likewise similar for both strains and immunization procedures.
摘要
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