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[1至39型腺病毒在婴幼儿及成人中的感染率]

[Infection rate with adenivirus 1 to 39 in infants and adults].

作者信息

Fatz W, Wigand R

出版信息

Immun Infekt. 1985 May;13(3):108-12.

PMID:2408993
Abstract

To study the infection rate with adenoviruses (Ad) in infants, sera from 75 infants aged 8 to 26 months were tested for neutralizing antibodies against Ad 1 to 39. Antibodies against Ad 1, 2, 5, and 6 were frequently found, against Ad 7 more rarely, whereas one serum reacted with each Ad 3, 4, 18, 31, and 37 and none with all other types. A significant association of positive reactions against several or all of Ad 1, 2, 5, and 6 was observed in neutralization, but not in hemagglutination inhibition, probably due to a subgenus-specific antibody response. The titer of neutralizing antibodies in human gammaglobulin was determined as an estimate for the prevalence of Ad 1 to 39 in the general population.

摘要

为研究腺病毒(Ad)在婴儿中的感染率,检测了75名8至26个月大婴儿的血清中针对Ad 1至39的中和抗体。针对Ad 1、2、5和6的抗体很常见,针对Ad 7的抗体较少见,而一份血清与Ad 3、4、18、31和37分别发生反应,与其他所有类型均无反应。在中和试验中观察到针对Ad 1、2、5和6中的几种或全部的阳性反应之间存在显著关联,但在血凝抑制试验中未观察到,这可能是由于亚属特异性抗体反应所致。测定了人丙种球蛋白中中和抗体的滴度,以估计Ad 1至39在普通人群中的流行率。

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