Indomethacin enhances in vitro histamine release induced by anti-IgE and Ca-ionophore but inhibits C5a-induced release reactions from basophils of atopics and normals.

Preincubation of peripheral leukocytes from atopics and normals significantly enhanced histamine release induced by anti-IgE and calcium ionophore. On the other hand, there was a significant inhibition (ca. 40%) of C5a-induced histamine release by indomethacin both in atopics and controls. In the group of patients with atopic eczema, anti-IgE-induced histamine release was significantly higher than in controls both without and with indomethacin.