Anichini A, Ress S, Strassmann G, Bach F H
Hum Immunol. 1985 Jun;13(2):139-43. doi: 10.1016/0198-8859(85)90020-5.
Monoclonal antibodies directed at monomorphic determinants on A,B,C (w6/32) or DR (L243, S4/24, S8/8) HLA antigens were used to inhibit the cytotoxic activity of class I- or class II-reactive CTL clones. Anti-class I (HLA-Bw62) cytotoxic T lymphocyte CTL clones were inhibited by w6/32, but not by L243, when tested on PHA blasts and LCL as targets. Interestingly, S4/24 and S8/8 demonstrated a differential blocking ability of class I reactive clones; these two monoclonal antibodies could not block Bw62-directed CTL clones when using PHA blasts as targets but strongly inhibited the cytotoxic activity of the same clones on LCLs as targets.
针对A、B、C（w6/32）或DR（L243、S4/24、S8/8）HLA抗原上单一型决定簇的单克隆抗体被用于抑制I类或II类反应性CTL克隆的细胞毒性活性。当以PHA刺激的淋巴细胞和LCL作为靶细胞进行检测时，抗I类（HLA - Bw62）细胞毒性T淋巴细胞CTL克隆被w6/32抑制，但不被L243抑制。有趣的是，S4/24和S8/8对I类反应性克隆表现出不同的阻断能力；当以PHA刺激的淋巴细胞作为靶细胞时，这两种单克隆抗体不能阻断Bw62导向的CTL克隆，但在以LCL作为靶细胞时能强烈抑制相同克隆的细胞毒性活性。
