Giannouli Christina C, Chandris Panagiotis, Proia Richard L
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Biochim Biophys Acta. 2014 May;1841(5):738-44. doi: 10.1016/j.bbalip.2013.09.012. Epub 2013 Oct 1.
Sphingosine-1-phosphate (S1P) is a bioactive lipid that provides cellular signals through plasma membrane G protein-coupled receptors. The S1P receptor signaling system has a fundamental and widespread function in licensing the exit and release of hematopoietically derived cells from various tissues into the circulation. Although the outlines of the mechanism have been established through genetic and pharmacologic perturbations, the temporal and spatial dynamics of the cellular events involved have been unclear. Recently, two-photon intravital imaging has been applied to living tissues to visualize the cellular movements and interactions that occur during egress processes. Here we discuss how some of these recent findings provide a clearer picture regarding S1P receptor signaling in modulating cell egress into the circulation. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
鞘氨醇-1-磷酸（S1P）是一种生物活性脂质，可通过质膜G蛋白偶联受体传递细胞信号。S1P受体信号系统在许可造血来源的细胞从各种组织进入循环的过程中具有基本且广泛的功能。尽管通过基因和药理学扰动已经确立了该机制的大致轮廓，但所涉及的细胞事件的时空动态尚不清楚。最近，双光子活体成像已应用于活体组织，以可视化在细胞外排过程中发生的细胞运动和相互作用。在这里，我们讨论这些最新发现如何为S1P受体信号在调节细胞进入循环中的作用提供更清晰的图景。本文是名为“鞘脂生物学新前沿”的特刊的一部分。
