Nuffield Department of Clinical Neurosciences and Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Nuffield Department of Clinical Neurosciences and Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Biol Psychiatry. 2014 Feb 15;75(4):269-75. doi: 10.1016/j.biopsych.2013.07.040. Epub 2013 Oct 3.
In the last decade, autoantibodies targeting proteins on the neuronal surface and that are believed to be directly pathogenic have been described in patients with autoimmune encephalitis. Since then, new antigenic targets have been discovered, and new clinical phenotypes have been recognized. The psychotic disorders are one example of this expanding spectrum. Here, we consider the defining criteria of antibody-mediated central nervous system disease and the extent to which the psychiatric data currently satisfy those criteria. We discuss the implications these findings have for our understanding, nosology, and treatment of psychiatric disorders.
在过去的十年中，人们在自身免疫性脑炎患者中描述了针对神经元表面蛋白的自身抗体，这些自身抗体被认为是直接致病的。从那时起，新的抗原靶标被发现，新的临床表型被认识到。精神障碍就是这种不断扩大的疾病谱的一个例子。在这里，我们考虑了抗体介导的中枢神经系统疾病的定义标准，以及目前精神科数据在多大程度上满足这些标准。我们讨论了这些发现对我们理解、分类和治疗精神障碍的意义。
