Pommergaard Hans-Christian, Burcharth Jakob, Rosenberg Jacob, Raskov Hans
J Chemother. 2014 Apr;26(2):105-10. doi: 10.1179/1973947813Y.0000000117. Epub 2013 Dec 6.
Non-melanoma skin cancer (NMSC) is the most common form of skin cancer. Owing to the significant adverse effects of existing treatments, alternatives are needed. The aim of this study was to evaluate the use of topically administered combination therapy and 5-flurouracil (5-FU) for the treatment of UVB induced NMSC in a mouse model. Ninety-six SKH-1 mice were randomized to one placebo group and two treatment groups (diclofenac+calcitriol+difluoromethylornithine (DFMO) and 5-FU). After UVB radiation for 20 weeks, the mice with tumours were treated topically for the following 17 weeks. Both treatments significantly reduced the number of tumours, number of mice with tumours as well as tumour area size compared with placebo. As the clinical use of 5-FU may induce more adverse effects, a combination of diclofenac+calcitriol+DFMO could be a promising alternative. Human studies are warranted to determine the beneficial effects and possible adverse effects of this new treatment.
非黑色素瘤皮肤癌（NMSC）是最常见的皮肤癌形式。由于现有治疗方法存在显著的不良反应，因此需要替代方案。本研究的目的是评估局部应用联合疗法和5-氟尿嘧啶（5-FU）在小鼠模型中治疗紫外线B（UVB）诱导的NMSC的效果。96只SKH-1小鼠被随机分为一个安慰剂组和两个治疗组（双氯芬酸+骨化三醇+二氟甲基鸟氨酸（DFMO）组和5-FU组）。在UVB照射20周后，对患有肿瘤的小鼠进行接下来17周的局部治疗。与安慰剂相比，两种治疗方法均显著减少了肿瘤数量、患肿瘤小鼠的数量以及肿瘤面积大小。由于5-FU的临床应用可能会引发更多不良反应，双氯芬酸+骨化三醇+DFMO联合使用可能是一种有前景的替代方案。有必要开展人体研究以确定这种新治疗方法的有益效果和可能的不良反应。
