Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, NYC, NY 10032, United States; Columbia Stem Cell Initiative, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, NYC, NY 10032, United States.
Curr Opin Neurobiol. 2013 Dec;23(6):935-42. doi: 10.1016/j.conb.2013.09.004. Epub 2013 Oct 1.
Stem cells persist in specialized niches in the adult mammalian brain. Emerging findings highlight the complexity and heterogeneity of different compartments in the niche, as well as the presence of local signaling microdomains. Stem cell quiescence and activation are regulated not only by anchorage to the niche and diffusible signals, but also by biophysical properties, including fluid dynamics. Importantly, the adult neural stem cell niche integrates both local and systemic changes, reflecting the physiological state of the organism. Moreover niche signaling is bidirectional, with stem cells and their progeny and niche cells dynamically interacting with each other during homeostasis, regeneration and aging.
干细胞存在于成年哺乳动物大脑的特定龛位中。新出现的研究结果强调了龛位中不同隔室的复杂性和异质性，以及局部信号微域的存在。干细胞的静止和激活不仅受到与龛位的锚定和弥散信号的调节，还受到包括流体动力学在内的生物物理特性的调节。重要的是，成年神经干细胞龛位整合了局部和全身变化，反映了生物体的生理状态。此外，龛位信号是双向的，干细胞及其后代和龛位细胞在稳态、再生和衰老过程中动态地相互作用。
