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胶质纤维酸性蛋白(GFAP):分化型星形胶质细胞中胶质中间丝的主要蛋白质。

Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes.

作者信息

Eng L F

出版信息

J Neuroimmunol. 1985 Jun;8(4-6):203-14. doi: 10.1016/s0165-5728(85)80063-1.

DOI:10.1016/s0165-5728(85)80063-1
PMID:2409105
Abstract

The glial fibrillary acidic protein (GFA protein or GFAP) is the major protein constituent of glial intermediate filaments in differentiated fibrous and protoplasmic astrocytes of the central nervous system. Proteins having similar molecular weights, isoelectric points, and immunoreactivity with GFAP have been found in cells of neural crest and ectodermal origin. A putative function ascribed to glial filaments is its role as a component of the cytoskeleton in defining and maintaining the shape of the astrocyte. Since 1980, over 350 reports have utilized antisera to GFAP for immunochemical and immunocytochemical studies.

摘要

胶质纤维酸性蛋白(GFA蛋白或GFAP)是中枢神经系统中分化的纤维型和原浆型星形胶质细胞内胶质中间丝的主要蛋白质成分。在神经嵴和外胚层来源的细胞中发现了分子量、等电点和与GFAP免疫反应性相似的蛋白质。胶质丝的一个假定功能是作为细胞骨架的组成部分,在定义和维持星形胶质细胞的形状方面发挥作用。自1980年以来,已有超过350篇报告使用抗GFAP血清进行免疫化学和免疫细胞化学研究。

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Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes.胶质纤维酸性蛋白(GFAP):分化型星形胶质细胞中胶质中间丝的主要蛋白质。
J Neuroimmunol. 1985 Jun;8(4-6):203-14. doi: 10.1016/s0165-5728(85)80063-1.
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