Garbutt Jane M, Conlon Bridget, Sterkel Randall, Baty Jack, Schechtman Kenneth B, Mandrell Kathy, Leege Erin, Gentry Shannon, Stunk Robert C
1Washington University in St. Louis, St. Louis, MO, USA.
Clin Pediatr (Phila). 2013 Nov;52(11):1014-21. doi: 10.1177/0009922813504823. Epub 2013 Oct 3.
Background. Although common practice, evidence to support treatment of croup with prednisolone is scant. Methods. We conducted a community-based randomized trial to compare the effectiveness of prednisolone (2 mg/kg/d for 3 days, n = 41) versus 1 dose of dexamethasone (0.6 mg/kg) and 2 doses of placebo (n = 46). Participants were children 1 to 8 years old with croup symptoms ≤48 hours, categorized as mild (42%) or moderate (58%). Results. There were no differences for those treated with dexamethasone or prednisolone for additional health care for croup (2% vs 7%, P = .34), duration of croup symptoms (2.8 vs 2.2 days, P = .63), nonbarky cough (6.1 vs 5.9 days, P = .81), nights with disturbed sleep for the parent (0.68 vs 1.21 nights, P = .55), and days with stress (1.39 vs 1.56 days, P = .51). Conclusion. There were no detected differences in outcomes between the 2 croup treatments for either child or parent.
背景。尽管使用泼尼松龙治疗哮吼是常见的做法，但支持该治疗方法的证据却很少。方法。我们开展了一项基于社区的随机试验，比较泼尼松龙（2毫克/千克/天，共3天，n = 41）与1剂地塞米松（0.6毫克/千克）及2剂安慰剂（n = 46）的疗效。参与者为1至8岁、哮吼症状持续时间≤48小时的儿童，分为轻度（42%）或中度（58%）。结果。接受地塞米松或泼尼松龙治疗的患儿因哮吼接受额外医疗护理的情况（2%对7%，P = 0.34）、哮吼症状持续时间（2.8天对2.2天，P = 0.63）、非犬吠样咳嗽（6.1天对5.9天，P = 0.81）、家长睡眠受干扰的夜晚数（0.68晚对1.21晚，P = 0.55）以及感到压力的天数（1.39天对1.56天，P = 0.51）均无差异。结论。两种哮吼治疗方法在患儿或家长的治疗结果方面均未发现差异。
