Quintero Gabriel C
Florida State University - Panama, Neuroscience, Republic of Panama; Smithsonian Tropical Research Institute (STRI), Balboa, Republic of Panama.
J Pain Res. 2013 Sep 19;6:713-25. doi: 10.2147/JPR.S45958.
Pain is an intricate phenomenon composed of not only sensory-discriminative aspects but also of emotional, cognitive, motivational, and affective components. There has been ample evidence for the existence of an extensive cortical network associated with pain processing over the last few decades. This network includes the anterior cingulate cortex, forebrain, insular cortex, ventrolateral orbital cortex, somatosensory cortex, occipital cortex, retrosplenial cortex, motor cortex, and prefrontal cortex. Diverse neurotransmitters participate in the cortical circuits associated with pain processing, including glutamate, gamma-aminobutyric acid, dopamine, and opioids. This work examines recent rodent studies about cortical modulation of pain, mainly at a molecular level.
疼痛是一种复杂的现象，不仅由感觉辨别方面组成，还包括情感、认知、动机和情感成分。在过去几十年里，有充分的证据表明存在一个与疼痛处理相关的广泛皮质网络。这个网络包括前扣带回皮质、前脑、岛叶皮质、腹外侧眶额皮质、体感皮质、枕叶皮质、压后皮质、运动皮质和前额叶皮质。多种神经递质参与与疼痛处理相关的皮质回路，包括谷氨酸、γ-氨基丁酸、多巴胺和阿片类物质。这项工作主要在分子水平上研究了最近关于啮齿动物疼痛皮质调制的研究。
