Petrossian Melita T, Paul Lisa R, Multhaupt-Buell Trisha J, Eckhardt Christine, Hayes Michael T, Duhaime Ann-Christine, Eskandar Emad N, Sharma Nutan
Department of Neurology, Brigham and Women's Hospital; and.
J Neurosurg Pediatr. 2013 Dec;12(6):582-7. doi: 10.3171/2013.8.PEDS13134. Epub 2013 Oct 4.
Pallidal deep brain stimulation (DBS) is a treatment option for those with early-onset dystonia. However, there are limited data on long-term outcome and treatment complications. The authors report on the short- and long-term effects of pallidal DBS in a cohort of patients with early-onset dystonia.
Fourteen consecutive pediatric patients with early-onset dystonia were systematically evaluated and treated. The duration of follow-up ranged from 16 to 84 months.
There were no immediate postoperative complications. At last follow-up, 12 of the 14 patients displayed a significant decline in the Burke-Fahn-Marsden Dystonia Rating Scale motor subscale score, with an average decrease of 62% ± 8.4%. The most common hardware complication was lead fracture (14.3%).
These data provide further evidence that DBS is a safe and effective treatment for those with earlyonset dystonia.
苍白球深部脑刺激术（DBS）是早发性肌张力障碍患者的一种治疗选择。然而，关于长期疗效和治疗并发症的数据有限。作者报告了苍白球DBS对一组早发性肌张力障碍患者的短期和长期影响。
对14例连续的早发性肌张力障碍儿科患者进行系统评估和治疗。随访时间为16至84个月。
术后无即刻并发症。在最后一次随访时，14例患者中有12例的伯克-法恩-马斯登肌张力障碍评定量表运动子量表评分显著下降，平均下降62%±8.4%。最常见的硬件并发症是电极导线断裂（14.3%）。
这些数据进一步证明DBS是早发性肌张力障碍患者的一种安全有效的治疗方法。
