Levenson J A, Simon A C, Safar M E
J Cardiovasc Pharmacol. 1985;7 Suppl 2:S115-20. doi: 10.1097/00005344-198507002-00022.
In patients with essential hypertension, vasodilating antihypertensive drugs act differently on small and large arteries. For similar blood pressure reductions, the diameter of the brachial artery may be unchanged (alpha- and beta-blocking drugs), decreased (dihydralazine), or increased (nitrates, renin-angiotensin and calcium-entry inhibitors). Increase in blood flow is due preferentially to an increase in blood flow velocity and is caused additionally by an increase in the diameter of the large artery. Increase in arterial compliance is observed only with nitrates, calcium-entry, and renin-angiotensin inhibitors. It is concluded that blood pressure reduction due to arteriolar vasodilatation may have various effects on the conducting function and the buffering function of large arteries, a point of importance in the prognosis of hypertensive cardiovascular disease.
在原发性高血压患者中，血管舒张性抗高血压药物对小动脉和大动脉的作用不同。为了使血压降低程度相似，肱动脉直径可能不变（α和β受体阻滞剂）、减小（双肼屈嗪）或增大（硝酸盐、肾素 - 血管紧张素和钙通道阻滞剂）。血流增加主要是由于血流速度增加，此外还由大动脉直径增加引起。仅在使用硝酸盐、钙通道阻滞剂和肾素 - 血管紧张素抑制剂时观察到动脉顺应性增加。由此得出结论，小动脉血管舒张导致的血压降低可能对大动脉的传导功能和缓冲功能产生多种影响，这在高血压心血管疾病的预后中具有重要意义。
