Faculty of Life Science, Bar-Ilan University, Ramat-Gan, Israel; Division of Peripheral Nerve Reconstruction, Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Int Rev Neurobiol. 2013;109:99-109. doi: 10.1016/B978-0-12-420045-6.00004-3.
Preservation of biochemical processes in muscles is a major challenge in patients with severe peripheral nerve injury. In this chapter, we address the effects of laser irradiation and biochemical transformation in muscle, using in vitro and in vivo experimental models. The authors attempt to explain the possible mechanism of laser phototherapy applied on skeletal muscle on the basis of literature review and new results. A detailed knowledge of the evolution of endplates acetylcholine receptors and creatine kinase activity following laser irradiation can help to understand the therapeutic effect of laser phototherapy on muscle. This study showed that the laser phototherapy increases biochemical activity in intact muscle and thus could have direct therapeutic applications on muscle, especially during progressive atrophy resulting from peripheral nerve injury.
在严重周围神经损伤的患者中，保持肌肉的生化过程是一个主要挑战。在本章中，我们使用体外和体内实验模型来解决肌肉中激光照射和生化转化的影响。作者试图根据文献综述和新的结果来解释应用于骨骼肌的激光光疗的可能机制。详细了解激光照射后终板乙酰胆碱受体和肌酸激酶活性的演变有助于理解激光光疗对肌肉的治疗效果。本研究表明，激光光疗可增加完整肌肉的生化活性，因此可能对肌肉具有直接的治疗应用，特别是在周围神经损伤引起的进行性萎缩期间。
