Andreo L, Soldera C B, Ribeiro B G, de Matos P R V, Bussadori S K, Fernandes K P S, Mesquita-Ferrari R A
Postgraduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Rua Vergueiro, 349, São Paulo, SP, CEP 01504001, Brazil.
Postgraduate Program in Rehabilitation Science, UNINOVE, São Paulo, SP, Brazil.
Lasers Med Sci. 2017 Dec;32(9):2155-2165. doi: 10.1007/s10103-017-2359-7. Epub 2017 Oct 23.
Phototherapy has demonstrated positive effects in the treatment of peripheral nerve injury, but there is a need to investigate the dosimetric parameters. Thus, the aim of the present study was to conduct a literature review on the effects of photobiomodulation with the use of low-level laser therapy (LLLT) on the treatment of peripheral nerve injury in experimental models. The databases of PubMed/MEDLINE, SCOPUS, and SPIE Digital Library were searched for articles on the use of LLLT in experimental models of peripheral nerve injury published in English between January 2007 and March 2016. The laser parameter variability was wavelength (632.8 to 980 nm), power (10 to 190 mW), and total energy (0.15 to 90 J) in pulsed or continuous wave and single or multiple points. Eighteen original articles demonstrating the effects of LLLT on the acceleration of functional recovery, morphological aspects as well as the modulation of the expression inflammatory cytokines, and growth factors were selected. LLLT is a viable phototherapeutic modality for the treatment of peripheral nerve injury, demonstrating positive effects on the neuromuscular repair process using either red or infrared light. The majority of studies used a power of up to 50 mW and total energy of up to 15 J administered to multiple points. The determination of these parameters is important to the standardization of a LLLT protocol to enhance the regeneration process following a peripheral nerve injury.
光疗已在周围神经损伤的治疗中显示出积极效果，但仍需要对剂量参数进行研究。因此，本研究的目的是对使用低强度激光疗法（LLLT）进行光生物调节对实验模型中周围神经损伤治疗效果的相关文献进行综述。检索了PubMed/MEDLINE、SCOPUS和SPIE数字图书馆数据库，查找2007年1月至2016年3月期间以英文发表的关于LLLT在周围神经损伤实验模型中应用的文章。激光参数的变化包括波长（632.8至980纳米）、功率（10至190毫瓦）以及脉冲或连续波、单点或多点照射时的总能量（0.15至90焦耳）。选取了18篇展示LLLT对功能恢复加速、形态学方面以及炎症细胞因子和生长因子表达调节作用的原创文章。LLLT是一种用于治疗周围神经损伤的可行光疗方式，使用红光或红外光对神经肌肉修复过程均显示出积极效果。大多数研究使用的功率高达50毫瓦，总能量高达15焦耳，多点给药。确定这些参数对于标准化LLLT方案以促进周围神经损伤后的再生过程很重要。
