Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell Metab. 2013 Oct 1;18(4):457-9. doi: 10.1016/j.cmet.2013.09.016.
Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descendants for up to four generations.
叶酸水平降低可导致发育缺陷和巨幼细胞性贫血。Padmanabhan 等人（2013 年）的研究表明，在叶酸代谢基因 Mtrr 发生突变的小鼠中，不仅突变后代会出现发育缺陷，而且在经过四代遗传的野生型后代中也会出现该缺陷。
