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本文引用的文献

1
A gut lipid messenger links excess dietary fat to dopamine deficiency.一种肠道脂质信使将过量饮食脂肪与多巴胺缺乏联系起来。
Science. 2013 Aug 16;341(6147):800-2. doi: 10.1126/science.1239275.
2
The endocrinology of food intake.摄食的内分泌学。
Nat Rev Endocrinol. 2013 Oct;9(10):584-97. doi: 10.1038/nrendo.2013.136. Epub 2013 Jul 23.
3
Metabolic and hedonic drives in the neural control of appetite: who is the boss?食欲的神经控制中的代谢和享乐驱动:谁是老大?
Curr Opin Neurobiol. 2011 Dec;21(6):888-96. doi: 10.1016/j.conb.2011.09.004. Epub 2011 Oct 6.
4
Reward, dopamine and the control of food intake: implications for obesity.奖励、多巴胺与食物摄入的控制:对肥胖的启示。
Trends Cogn Sci. 2011 Jan;15(1):37-46. doi: 10.1016/j.tics.2010.11.001. Epub 2010 Nov 24.
5
The lipid messenger OEA links dietary fat intake to satiety.脂质信使油酸乙醇酰胺(OEA)将膳食脂肪摄入与饱腹感联系起来。
Cell Metab. 2008 Oct;8(4):281-288. doi: 10.1016/j.cmet.2008.08.005.
6
Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats.肥胖倾向大鼠中脑边缘多巴胺胞吐缺陷的证据。
FASEB J. 2008 Aug;22(8):2740-6. doi: 10.1096/fj.08-110759. Epub 2008 May 13.
7
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.油酰乙醇胺引起摄食行为和运动活动变化的机制。
Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R729-37. doi: 10.1152/ajpregu.00029.2005. Epub 2005 May 5.
8
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha.油酰乙醇胺通过激活核受体PPAR-α来调节进食和体重。
Nature. 2003 Sep 4;425(6953):90-3. doi: 10.1038/nature01921.
9
An anorexic lipid mediator regulated by feeding.一种受进食调节的厌食性脂质介质。
Nature. 2001 Nov 8;414(6860):209-12. doi: 10.1038/35102582.

进食脂肪后产生的愉悦和平衡重叠。

Hedonic and homeostatic overlap following fat ingestion.

机构信息

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45237, USA.

出版信息

Cell Metab. 2013 Oct 1;18(4):459-60. doi: 10.1016/j.cmet.2013.09.012.

DOI:10.1016/j.cmet.2013.09.012
PMID:24093671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3869225/
Abstract

Ingestion of fatty foods increases dopamine release in the substantia nigra, producing a positive hedonic state. Tellez et al. (2013) demonstrate that an intestinal signal generated by fat consumption, oleoylethanolamide, stimulates central dopamine activity, thus regulating the reward value of fat and establishing a link between caloric-homeostatic and hedonic-homeostatic controllers.

摘要

进食高脂肪食物会增加黑质中的多巴胺释放,产生积极的愉悦状态。Tellez 等人(2013 年)证明,脂肪消耗产生的一种肠道信号,即油酰乙醇酰胺,会刺激中枢多巴胺活动,从而调节脂肪的奖赏价值,并在热量平衡和愉悦平衡控制器之间建立联系。