Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.
BMC Endocr Disord. 2013 Oct 7;13:42. doi: 10.1186/1472-6823-13-42.
Traditional lipid indices have been associated with type 2 diabetes, but it remains uncertain which lipid index is the best discriminator for diabetes. In this study, we aimed to assess lipoproteins, traditional lipid variables, and other variables to discover their association with diabetes in the Taiwanese population.
Data from a nationwide cross-sectional population-based survey of 3087 men and 3373 women in 2002 were analyzed in this study. All participants were assessed for anthropometry, glycosylated hemoglobin, fasting sugar and lipid profiles with triglycerides, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and apolipoprotein A1 (ApoA1) and B (ApoB). The ratio of LDL-C/HDL-C, ApoB/ApoA1, ApoB/LDL-C and ApoA1/HDL-C and other variables were analyzed to determine their potential roles in type 2 diabetes in the Taiwanese population. The Odds ratios (ORs) of the risk variables for diabetes were estimated using logistic regression and were adjusted for confounding factors.
The increased ratio of ApoA1/HDL-C was significantly associated with diabetes in men (top tertile vs. lowest: OR 2.98; 95% CI: 1.12 - 7.92; P-trend = 0.030) and women (top tertile vs. lowest: OR 2.15; 95% CI: 1.00 - 4.59; P-trend = 0.047). A modest increased diabetic risk was evident with ApoB/LDL-C in women (top tertile vs. lowest: OR 2.03; 95% CI: 1.07- 3.85; P-trend = 0.028), but not in men (top tertile v. lowest: OR 1.69; 95% CI: 0.79- 3.62; P-trend = 0.198).
ApoA1/HDL-C had a significant linear association with diabetes in both sexes and was superior to other lipid and lipoprotein variables among the general Taiwanese population.
传统的血脂指标与 2 型糖尿病有关，但哪种血脂指标对糖尿病的诊断最佳仍不确定。本研究旨在评估脂蛋白、传统血脂变量和其他变量，以发现它们与台湾人群糖尿病的关系。
本研究分析了 2002 年一项全国性横断面基于人群的 3087 名男性和 3373 名女性的数据。所有参与者均接受了人体测量、糖化血红蛋白、空腹血糖和血脂谱检查，包括甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白 A1（ApoA1）和 B（ApoB）。分析 LDL-C/HDL-C、ApoB/ApoA1、ApoB/LDL-C 和 ApoA1/HDL-C 等比值以及其他变量，以确定它们在台湾人群 2 型糖尿病中的潜在作用。使用逻辑回归估计糖尿病风险变量的比值比（OR），并调整混杂因素。
男性中，ApoA1/HDL-C 比值升高与糖尿病显著相关（最高三分位与最低三分位：OR 2.98；95%CI：1.12-7.92；P-trend=0.030），女性中，ApoA1/HDL-C 比值升高与糖尿病显著相关（最高三分位与最低三分位：OR 2.15；95%CI：1.00-4.59；P-trend=0.047）。女性中，ApoB/LDL-C 比值略有升高与糖尿病风险增加相关（最高三分位与最低三分位：OR 2.03；95%CI：1.07-3.85；P-trend=0.028），但男性中无此相关性（最高三分位与最低三分位：OR 1.69；95%CI：0.79-3.62；P-trend=0.198）。
ApoA1/HDL-C 与两性的糖尿病均有显著的线性关联，在台湾一般人群中优于其他血脂和脂蛋白变量。
