Huie M L, Gordon A S, Mirand E A, Leong S, Preti R A, Naughton B A
Life Sci. 1985 Jul 1;36(26):2459-62. doi: 10.1016/0024-3205(85)90141-9.
The effects of interferon (IF) on erythropoietin (Ep) action and production were studied in mice. In comparison to control animals, Ep action in exhypoxic, polycythemic mice was significantly decreased (p less than 0.05) following two low dose injections of IF (2.9-3.5 X 10(4) units). In addition, renal Ep production in normal intact mice was also significantly decreased (p less than 0.01) following a single injection of IF (5.4-6.3 X 10(4) units) and hypoxic exposure.
在小鼠中研究了干扰素（IF）对促红细胞生成素（Ep）作用及产生的影响。与对照动物相比，两次低剂量注射IF（2.9 - 3.5×10⁴单位）后，低氧性红细胞增多症小鼠的Ep作用显著降低（p < 0.05）。此外，单次注射IF（5.4 - 6.3×10⁴单位）并进行低氧暴露后，正常完整小鼠的肾脏Ep产生也显著降低（p < 0.01）。
