Zucali J R, Lee M, Mirand E A
J Lab Clin Med. 1978 Oct;92(4):648-55.
The addition of carbon dioxide during a short bout (6 to 24 hr) of hypoxia suppresses the production of Ep. The effects of carbon dioxide on Ep production and erythropoiesis were determined in hypoxic rats over a 6-day period. Carbon dioxide suppressed both renal and extrarenal Ep production induced by hypoxia. However, rats exposed to a hypoxic environment with 5% CO2 became as polycythemic as rats exposed to the same hypoxia without CO2. This may result from the following. (1) A factor other than Ep is involved in stimulating erythropoiesis in these animals. (2) The large amount of Ep produced during hypoxia is in excess, and only a small amount is needed to compensate for the hypoxia by producing increased numbers of RBCs. (3) A significant degree of hemoconcentration occured, resulting in the increased number of RBCs observed.
在短时间（6至24小时）缺氧期间添加二氧化碳可抑制促红细胞生成素（Ep）的产生。在6天的时间里，研究了二氧化碳对缺氧大鼠促红细胞生成素产生和红细胞生成的影响。二氧化碳抑制了缺氧诱导的肾脏和肾外促红细胞生成素的产生。然而，暴露于含5%二氧化碳的缺氧环境中的大鼠与暴露于相同缺氧环境但无二氧化碳的大鼠一样出现红细胞增多。这可能是由以下原因导致的。（1）这些动物中，除促红细胞生成素外，还有其他因素参与刺激红细胞生成。（2）缺氧期间产生的大量促红细胞生成素过量，通过产生更多数量的红细胞来补偿缺氧只需少量促红细胞生成素。（3）发生了显著程度的血液浓缩，导致观察到的红细胞数量增加。
