College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA; Indiana University Center for Aging Research, 410 West 10th Street, Indianapolis, IN 46202, USA; Regenstrief Institute, Inc, 410 West 10th Street, Indianapolis, IN 46202, USA; Department of Pharmacy, Wishard/Eskenazi Health Services, 1001 West 10th Street, Indianapolis, IN 46202, USA.
Clin Geriatr Med. 2013 Nov;29(4):873-93. doi: 10.1016/j.cger.2013.07.009.
The increasing prevalence of cognitive impairment among the older adult population warrants attention to the identification of practices that may minimize the progression of early forms of cognitive impairment, including the transitional stage of mild cognitive impairment (MCI), to permanent stages of dementia. This article identifies both markers of disease progress and risk factors linked to the progression of MCI to dementia. Potentially modifiable risk factors may offer researchers a point of intervention to modify the effect of the risk factor and to minimize the future burden of dementia.
随着老年人群体认知障碍的患病率不断上升,我们需要关注那些可能有助于减缓早期认知障碍(包括轻度认知障碍(MCI)的过渡阶段)向永久性痴呆阶段发展的实践。本文确定了与 MCI 向痴呆发展相关的疾病进展标志物和风险因素。潜在的可改变风险因素可能为研究人员提供一个干预点,以改变风险因素的影响,从而最大限度地减少未来痴呆的负担。