Eshkoor Sima Ataollahi, Hamid Tengku Aizan, Mun Chan Yoke, Ng Chee Kyun
Institute of Gerontology, Universiti Putra Malaysia, Selangor, Malaysia.
Clin Interv Aging. 2015 Apr 10;10:687-93. doi: 10.2147/CIA.S73922. eCollection 2015.
Mild cognitive impairment (MCI) is a common condition in the elderly. It is characterized by deterioration of memory, attention, and cognitive function that is beyond what is expected based on age and educational level. MCI does not interfere significantly with individuals' daily activities. It can act as a transitional level of evolving dementia with a range of conversion of 10%-15% per year. Thus, it is crucial to protect older people against MCI and developing dementia. The preventive interventions and appropriate treatments should improve cognitive performance, and retard or prevent progressive deficits. The avoidance of toxins, reduction of stress, prevention of somatic diseases, implementation of mental and physical exercises, as well as the use of dietary compounds like antioxidants and supplements can be protective against MCI. The modification of risk factors such as stopping smoking, as well as the treatment of deficiency in vitamins and hormones by correcting behaviors and lifestyle, can prevent cognitive decline in the elderly. The progressive increase in the growth rate of the elderly population can enhance the rate of MCI all over the world. There is no exact cure for MCI and dementia; therefore, further studies are needed in the future to determine causes of MCI and risk factors of progression from MCI to dementia. This will help to find better ways for prevention and treatment of cognitive impairment worldwide.
轻度认知障碍(MCI)是老年人中的常见状况。其特征在于记忆、注意力和认知功能的衰退,这种衰退超出了基于年龄和教育水平所预期的程度。MCI不会对个体的日常活动造成显著干扰。它可作为一种演变中的痴呆症的过渡阶段,每年的转化率在10%至15%之间。因此,保护老年人免受MCI和痴呆症的影响至关重要。预防性干预措施和适当的治疗应能改善认知表现,并延缓或预防渐进性缺陷。避免接触毒素、减轻压力、预防躯体疾病、进行心理和体育锻炼,以及使用抗氧化剂和补充剂等膳食化合物,都可能对MCI具有保护作用。通过纠正行为和生活方式来改变诸如戒烟等风险因素,以及治疗维生素和激素缺乏症,可预防老年人的认知衰退。老年人口增长率的逐步上升会提高全球MCI的发生率。目前尚无针对MCI和痴呆症的确切治愈方法;因此,未来需要进一步开展研究,以确定MCI的病因以及从MCI发展为痴呆症的风险因素。这将有助于找到在全球范围内预防和治疗认知障碍的更好方法。