Wong Erin, Hoskin Peter, Bedard Gillian, Poon Michael, Zeng Liang, Lam Henry, Vulpe Horia, Tsao May, Pulenzas Natalie, Chow Edward
Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom.
Radiother Oncol. 2014 Jan;110(1):61-70. doi: 10.1016/j.radonc.2013.09.004. Epub 2013 Oct 3.
The purpose of this review was to determine the efficacy of re-irradiation in patients with bone metastases. A literature search was conducted in Ovid Medline, OldMedline, Embase, Embase Classic, and Cochrane Central Register of Controlled Trials using relevant subject headings and keywords such as bone metastases, radiotherapy and palliative care. The resulting articles were sorted for inclusion for palliative external beam radiation retreatment response rate data. The literature search produced 2164 references and 15 articles were included in the final selection. Complete, partial and overall response rates were calculated to be 20%, 50% and 68%, respectively. Information on treatment toxicities was scarce. The efficacy of re-irradiation is comparable to initial radiation treatment. However, aspects of re-irradiation treatment including dose fractionation, related adverse events and toxicities require further corroboration.
本综述的目的是确定再程放疗对骨转移患者的疗效。使用骨转移、放射治疗和姑息治疗等相关主题词和关键词，在Ovid Medline、OldMedline、Embase、Embase Classic和Cochrane对照试验中央注册库中进行文献检索。对检索出的文章进行筛选，纳入有关姑息性外照射再程治疗反应率的数据。文献检索共获得2164篇参考文献，最终纳入15篇文章。计算得出完全缓解率、部分缓解率和总缓解率分别为20%、50%和68%。关于治疗毒性的信息很少。再程放疗的疗效与初始放疗相当。然而，再程放疗治疗的各个方面，包括剂量分割、相关不良事件和毒性，都需要进一步证实。
