Hernández Perella José Antonio, Mas Garriga Xavier, Riera Cervera Dolors, Quintanilla Castillo Roger, Gardini Campomanes Katharina, Torrabadella Fàbregas Jordi
EAP Santa Eulalia Sud, Institut Català de la Salut, L'Hospitalet de Llobregat, Barcelona, España.
Rev Esp Geriatr Gerontol. 2013 Nov-Dec;48(6):265-8. doi: 10.1016/j.regg.2013.04.004. Epub 2013 Oct 2.
To determine the prevalence and characteristics of inappropriate prescribing of drugs (IP) in patients >65 years-old evaluated by a primary care team (PCT), using the STOPP-START criteria.
Cross-sectional sample of patients older than 65 years-old with active clinical history in 2010, and who were attended in 13 urban clinics (systematic random sampling, expected IP prevalence of 40%, precision: 5% confidence level: 95%). Requirement was reviewed clinical histories in 2010, using the STOPP-START criteria.
A total of 363 patients were selected (56.7% women), mean age 75.2 years (SD: 7.02). The most frequent diseases were cardiovascular (76.9%) and osteoarticular (57.6%) diseases, and the average number of prescription drugs was 4.9 (SD: 3.32). IP was detected in 170 patients (46.8%; 95% CI: 41.7-52.0%), 42% in men (95% CI: 34.3-49.8%) and 46.6% in women (95% CI: 39.8-53.4%), with no differences between sexes (P=.386), with a higher prevalence if polypharmacy or comorbidity were present (P<.001). The STOPP criteria were met in 131 patients (36.1%; 95% CI: 31.1-41.0%), and START criteria in 73 (20.1%; 95% CI: 16-24.2%), with no difference between sexes (P=.623 for STOPP, and P=.678 for START). The most frequent STOPP criteria were observed in the musculoskeletal system (50 patients, 38.2%; 95% CI: 29.8-46.5%) and START endocrinology indicators (38 patients, 52.1%; 95% CI: 40.0-63.9%).
The STOPP-START tool detected and systematised IP in a high percentage of elderly patients treated by a PCT, and can promote improvement in prescribing strategies.
采用STOPP-START标准,确定由初级保健团队(PCT)评估的65岁以上患者中不适当用药(IP)的患病率及特征。
对2010年有活跃临床病史且在13家城市诊所就诊的65岁以上患者进行横断面抽样(系统随机抽样,预期IP患病率为40%,精度:5%,置信水平:95%)。要求使用STOPP-START标准回顾2010年的临床病史。
共选取363例患者(女性占56.7%),平均年龄75.2岁(标准差:7.02)。最常见的疾病是心血管疾病(76.9%)和骨关节疾病(57.6%),平均处方药数量为4.9种(标准差:3.32)。170例患者检测到IP(46.8%;95%置信区间:41.7 - 52.0%),男性为42%(95%置信区间:34.3 - 49.8%),女性为46.6%(95%置信区间:39.8 - 53.4%),性别间无差异(P = 0.386),如果存在多重用药或合并症,患病率更高(P < 0.001)。131例患者符合STOPP标准(36.1%;95%置信区间:31.1 - 41.0%),73例符合START标准(20.1%;95%置信区间:16 - 24.2%),性别间无差异(STOPP标准P = 0.623,START标准P = 0.678)。最常见的STOPP标准见于肌肉骨骼系统(50例患者,38.2%;95%置信区间:29.8 - 46.5%),START标准见于内分泌指标(含38例患者,52.1%;95%置信区间:40.0 - 63.9%)。
STOPP-START工具在PCT治疗的高比例老年患者中检测并系统化了IP,可促进处方策略的改进。