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[根据STOPP/START标准(STARTREC研究)评估西班牙老年人群潜在不适当处方情况]

[Potentially inappropriate prescribing in older Spanish population according to STOPP/START criteria (STARTREC study)].

作者信息

Cruz-Esteve Inés, Marsal-Mora Josep Ramón, Galindo-Ortego Gisela, Galván-Santiago Leonardo, Serrano-Godoy Marcos, Ribes-Murillo Esther, Real-Gatius Jordi

机构信息

Centro de Atención Primaria Primer de Maig, Institut Català de la Salut, Lleida, España; Unitat de Suport a la Recerca Lleida-Pirineus, Institut d'Investigació en Atenció Primària J Gol (IDIAP J Gol), Lleida, España.

Unitat de Suport a la Recerca Lleida-Pirineus, Institut d'Investigació en Atenció Primària J Gol (IDIAP J Gol), Lleida, España.

出版信息

Aten Primaria. 2017 Mar;49(3):166-176. doi: 10.1016/j.aprim.2016.02.013. Epub 2016 Sep 29.

Abstract

OBJECTIVE

Rational prescribing in older people is a priority for health care organizations. The STOPP/START screening tool has been developed to identify potentially inappropriate prescribing (PIP) in individuals. In a primary care setting, STOPP/START can estimate PIP prevalence and related factors at population level. The aim of this study is to measure the prevalence rates of PPI in elderly population using clinical and prescription claim databases.

DESIGN

Cross-sectional population study.

SETTINGS

Primary Care, Lleida Health Region, Spain.

PARTICIPANTS

45.408 patients 70 years old and over, attended in the primary health care centers at least once the last year.

METHODS

43 STOPP and 12 START criteria are applied to their 2012 clinical and prescription records. Logistic regression models are adjusted to determine PIP association with several factors.

RESULTS

45,408 patients are included. The mean age is 79.7 years, 58% being female. The overall prevalence of PPI is 58.1%. According to STOPP, the most common drugs identified are benzodiazepines, non-steroidal anti-inflammatory drugs and proton pump inhibitors; according to START, osteoporosis treatments, antiplatelet agents, statins, metformin and beta blockers. PIP increases with age and polypharmacy and it is higher in long-term care facilities residents and patients receiving home health care.

CONCLUSIONS

In our Health Region, at least 50% of the population aged 70 or older has one or more PIP, according to STOPP/START criteria.

摘要

目的

老年人合理用药是医疗机构的一项优先任务。已开发出 STOPP/START 筛查工具来识别个体中潜在的不适当用药(PIP)。在初级保健环境中,STOPP/START 可以在人群层面估计 PIP 的患病率及相关因素。本研究的目的是利用临床和处方索赔数据库测量老年人群中 PIP 的患病率。

设计

横断面人群研究。

地点

西班牙莱里达卫生区的初级保健机构。

参与者

45408 名 70 岁及以上的患者,去年至少在初级保健中心就诊过一次。

方法

将 43 条 STOPP 标准和 12 条 START 标准应用于他们 2012 年的临床和处方记录。调整逻辑回归模型以确定 PIP 与多种因素的关联。

结果

纳入 45408 名患者。平均年龄为 79.7 岁,58%为女性。PIP 的总体患病率为 58.1%。根据 STOPP,识别出的最常见药物是苯二氮䓬类、非甾体抗炎药和质子泵抑制剂;根据 START,是骨质疏松症治疗药物、抗血小板药物、他汀类药物、二甲双胍和β受体阻滞剂。PIP 随年龄和用药种类增加而升高,在长期护理机构居民和接受家庭医疗护理的患者中更高。

结论

根据 STOPP/START 标准,在我们的卫生区,至少 50%的 70 岁及以上人群存在一种或多种 PIP。

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