放疗与胃食管反流病在导致气管食管发声康复失败中的关系。
Relationship between radiotherapy and gastroesophageal reflux disease in causing tracheoesophageal voice rehabilitation failure.
机构信息
Department of Medical Surgical Specialties, ENT Unit, University of Catania, Catania, Italy.
Department of Medical Surgical Specialties, ENT Unit, University of Catania, Catania, Italy.
出版信息
J Voice. 2014 Mar;28(2):245-9. doi: 10.1016/j.jvoice.2013.08.008. Epub 2013 Oct 2.
OBJECTIVE
The objective was to analyze the association of radiotherapy with gastroesophageal reflux as determinant of fistula related pathology, in voice prosthesis patients.
STUDY DESIGN
Retrospective study.
METHODS
Sixty-one laryngectomy patients were enrolled between 2005 and 2012. All patients underwent phonatory rehabilitation with voice prosthesis, along with evidence of gastroesophageal reflux disease, for which proton pump inhibitors (PPIs) were prescribed. We analyzed the occurrence of fistula-related problems among patients who received postoperative radiotherapy and those patients who did not.
RESULTS
We observed a higher rate of failure of speech rehabilitation in laryngectomy patients with gastroesphageal reflux: this occurred when they had a history of postoperative radiotherapy (45%) compared with patients who did not (17%) (P < 0.05), although all patients were treated with PPIs.
CONCLUSION
Our results seem to confirm the importance of postoperative radiotherapy with gastroesophageal reflux for the determinism of fistula-related problems.
目的
分析放疗与胃食管反流的相关性，胃食管反流是决定发生发声重建术后瘘相关病变的因素。
研究设计
回顾性研究。
方法
2005 年至 2012 年间共纳入 61 例喉切除术患者。所有患者均使用声门重建术后发声假体进行语音康复，并证实存在胃食管反流病，为其开具质子泵抑制剂（PPIs）。我们分析了术后接受放疗与未接受放疗的患者发生瘘相关问题的情况。
结果
我们观察到胃食管反流的喉切除患者的语音康复失败率较高：在有术后放疗史的患者中发生率为 45%，而在未接受放疗的患者中发生率为 17%（P<0.05），尽管所有患者均接受了 PPI 治疗。
结论
我们的结果似乎证实了术后放疗与胃食管反流对瘘相关问题的决定作用。
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