Teo Wei-Peng, Rodrigues Julian P, Mastaglia Frank L, Thickbroom Gary W
Australian Neuro-Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Western Australia, Australia.
Australian Neuro-Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Western Australia, Australia.
Clin Neurophysiol. 2014 Mar;125(3):562-8. doi: 10.1016/j.clinph.2013.09.004. Epub 2013 Oct 1.
In healthy subjects, fatiguing exercises induce a period of post-exercise corticomotor depression (PECD) that is absent in Parkinson's disease (PD). Our objective is to determine the time-course of corticomotor excitability changes following a 10-s repetitive index finger flexion-extension task performed at maximal voluntary rate (MVR) and a slower sustainable rate (MSR) in PD patients OFF and ON levodopa.
In 11 PD patients and 10 healthy age-matched controls, motor evoked potentials (MEPs) were recorded from the extensor indicis proprius (EIP) and first dorsal interosseous (FDI) muscles of the dominant arm immediately after the two tasks and at 2-min intervals for 10 min.
In the OFF condition the PECD was absent in the two test muscles after both the MVR and MSR tasks. In the ON condition finger movement kinematics improved and a period of PECD comparable to that in controls was present after both tasks.
The absence of PECD in PD subjects off medication indicates a persisting increase in corticomotor excitability after non-fatiguing repetitive finger movement that is reversed by levodopa.
Dopamine depletion is associated with impaired modulation of corticomotor excitability after non-fatiguing repetitive finger movement.
在健康受试者中，疲劳运动可诱发运动后皮质运动抑制期（PECD），而帕金森病（PD）患者不存在此现象。我们的目的是确定帕金森病患者在未服用左旋多巴和服用左旋多巴时，以最大自主频率（MVR）和较慢可持续频率（MSR）进行10秒重复性食指屈伸任务后皮质运动兴奋性变化的时间进程。
对11例帕金森病患者和10名年龄匹配的健康对照者，在两项任务完成后立即以及之后每隔2分钟记录优势臂示指固有伸肌（EIP）和第一背侧骨间肌（FDI）的运动诱发电位（MEP），持续10分钟。
在未服用左旋多巴状态下，MVR和MSR任务后两块测试肌肉均未出现PECD。在服用左旋多巴状态下，手指运动学得到改善，两项任务后均出现了与对照组相当的PECD期。
未服药的帕金森病患者不存在PECD，表明在非疲劳性重复性手指运动后皮质运动兴奋性持续增加，而左旋多巴可使其逆转。
多巴胺耗竭与非疲劳性重复性手指运动后皮质运动兴奋性调节受损有关。
