1508 NW 35th Way, Gainesville, FL 32605, United States.
Med Hypotheses. 2013 Dec;81(6):1002-3. doi: 10.1016/j.mehy.2013.09.014. Epub 2013 Sep 17.
Sodium chloride intake might increase the risk for the development of autoimmune diseases by increasing the activity of the p38/MAPK pathway in CD4+ cells thereby producing pathogenic TH17 cells which are inflammatory. Two factors (muscarinic and beta adrenergic stimulation), already shown to potentiate each other's toxic effects in whole mice, and have combined amplified sub lethal effects on mouse T cells, can have the same effect on CD4+ signaling pathways as sodium chloride. Sick 1991 Gulf War veterans express elevated Th17 cytokine activity, and therefore may have autoimmune illnesses caused directly by the above mentioned exposures.
氯化钠的摄入可能会通过增加 CD4+ 细胞中 p38/MAPK 通路的活性，从而产生炎症性的致病性 TH17 细胞，从而增加自身免疫性疾病的风险。已经有研究表明，两种因素（毒蕈碱和β肾上腺素刺激）在整体小鼠中可以增强彼此的毒性作用，并且对小鼠 T 细胞具有联合增强的亚致死作用，它们对 CD4+信号通路的作用与氯化钠相同。患病的 1991 年海湾战争老兵表达出升高的 Th17 细胞因子活性，因此可能直接由上述暴露引起自身免疫性疾病。
