Med Hypotheses. 2012 Aug;79(2):283-4. doi: 10.1016/j.mehy.2012.04.043. Epub 2012 May 24.
Gulf War illnesses (GWI share many of the features of chronic fatigue syndrome (CFS) and both CFS and GWI may be the result of chronic immune system processes. The main suspected cause for GWI, the drug pyridostigmine bromide (PB), has been shown to cause neuronal damage from reactive oxygen species (ROS). ROS have been associated with IgM mediated autoimmune responses against ROS induced neoepitopes in depressed patients and this may also apply to CFS. It therefore follows that the drug used in the Gulf War caused ROS, the ROS modified native molecules, and that this trigged the autoimmune condition we refer to as Gulf War illnesses. Similar mechanisms may apply to other autoimmune illnesses.
海湾战争病（GWI）与慢性疲劳综合征（CFS）有许多共同特征，CFS 和 GWI 可能都是慢性免疫系统过程的结果。GWI 的主要可疑原因，药物吡哆醇溴化物（PB），已被证明会导致活性氧（ROS）引起的神经元损伤。ROS 与抑郁患者针对 ROS 诱导的新表位的 IgM 介导的自身免疫反应有关，这也可能适用于 CFS。因此，可以推断出在海湾战争中使用的药物会引起 ROS，ROS 会修饰天然分子，并且这会引发我们称为海湾战争病的自身免疫状况。类似的机制可能适用于其他自身免疫性疾病。
