Nagy Dániel Tamás, Fülesdi Béla, Hallay Judit
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Aneszteziológiai és Intenzív Terápiás Tanszék Debrecen Nagyerdei krt. 98. 4032.
Orv Hetil. 2013 Oct 13;154(41):1636-40. doi: 10.1556/OH.2013.29728.
The cell-membrane toxicity of reactive oxygen and nitrogen species (RONS) plays an increasing role in the pathomechanism of gastrointestinal tract diseases. Trace elements are important parts of antioxidant protecting system, especially the selenium (Se), which, in the form of glutathione peroxidase contributes to the immunity of the gut (GALT). Due to the absorptional disorders and consequent malnutrition observed in the course of inflammatory bowel diseases (IBD) an important role is associated with nutritional therapy, including energy-, protein- and trace element-support. Human studies show, that IBD is mostly accompanied by lower serum Se concentrations, reduced antoxidant and increased proinflammatory activity. Adequate Se-replacement may reduce the severity of organ failure and infections, but not mortality. However, it is encouraging that in animal studies obvious preventive effect of Se has been found on IBD and chronic inflammation induced colon cancer .
活性氧和氮物种（RONS）的细胞膜毒性在胃肠道疾病的发病机制中发挥着越来越重要的作用。微量元素是抗氧化保护系统的重要组成部分，尤其是硒（Se），它以谷胱甘肽过氧化物酶的形式有助于肠道免疫（GALT）。由于在炎症性肠病（IBD）过程中观察到吸收障碍及随之而来的营养不良，营养治疗（包括能量、蛋白质和微量元素支持）具有重要作用。人体研究表明，IBD大多伴有血清硒浓度降低、抗氧化剂减少和促炎活性增加。充足的硒替代可能会降低器官衰竭和感染的严重程度，但不能降低死亡率。然而，令人鼓舞的是，在动物研究中发现硒对IBD和慢性炎症诱导的结肠癌具有明显的预防作用。
