Hassan Syed A, Amer Syed, Qureshi Waqas, Alirhayim Zaid, Kuriakose Philip
Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Hematol Oncol Stem Cell Ther. 2013 Sep-Dec;6(3-4):101-4. doi: 10.1016/j.hemonc.2013.08.004. Epub 2013 Oct 1.
There is limited data on the occurrence of coronary artery disease (CAD) in patients with Von Willebrand disease and the literature is even scarce on their management. We at our institute reviewed the medical records of 198 patients with Von Willebrand disease over a period of 15years, of which 6 were found to have symptomatic CAD. Acute coronary syndrome was noted in 3 patients while the remaining 3 had stable angina. Cardiac catheterization showed that left main coronary artery was the culprit vessel in all of these patients. In terms of management, stents were placed in 3 patients, two of them underwent coronary artery bypass grafting, and the remaining one patient was medically managed. Aspirin, and in some patients clopidogrel, was well tolerated with minimal side effects.
关于血管性血友病患者中冠状动脉疾病（CAD）的发生情况，数据有限，而关于其治疗的文献更是稀少。我们所在的机构回顾了15年间198例血管性血友病患者的病历，其中6例被发现患有有症状的CAD。3例患者出现急性冠状动脉综合征，其余3例患有稳定型心绞痛。心脏导管检查显示，所有这些患者的罪犯血管均为左主干冠状动脉。在治疗方面，3例患者置入了支架，其中2例接受了冠状动脉旁路移植术，其余1例接受药物治疗。阿司匹林以及部分患者使用的氯吡格雷耐受性良好，副作用极小。
